Synthetic DNA for Cell?Surface Engineering

The cell membrane is not only a physical barrier, but also functional organelle that regulates the communication between and its environment. ability to functionalize with synthetic molecules or nanostructures would advance cellular functions beyond what evolution has provided. aim of this Minireview introduce recent progress in using DNA DNA-based for cell-surface engineering. We first chemical conjugation binding methods monovalent polyvalent surface then application these either promotion inhibition cell–environment numerous applications, including cell–cell recognition, regulation intracellular pathways, protection therapeutic cells, sensing extracellular microenvironments. Lastly, we summarize current challenges existing area potential solutions solve challenges.